Synthesis and characterization of polymeric nanoemulsions of xanthan gum and arabic gum encapsulating Eucalyptuscitriodora l. essential oil.
DOI:
https://doi.org/10.24979/ambiente.v1i1.929Keywords:
Nanoemulsions, Encapsulation, Particle size, StabilityAbstract
Oil-in-water nanoemulsions are drug delivery systems that consist of the formation of amphipathic particles for encapsulating oil molecules. In this work, Nanoemulsions of xanthan gum and gum arabic were developed with Eucalyptus citriodora L. oil using the high energy technique, where the matrix type, the surfactant content and the essential oil content were varied in order to produce stable formulations. Nanoemulsions were evaluated in relation to their physical and chemical characteristics: macroscopic stability, viscosity and particle size. The viscosities of the formulations corroborated the results of particle size, where they showed an increase in viscosity as a function of size. The study showed that the samples that had the lowest proportions, gum / oil of 1: 1 and surfactant / oil of 1: 2, showed better results in the formation of nanometric micelles. These variations in the compositions show how the amount of surfactant, oil phase and natural polymer influences the development of the colloidal system. With these results, it is possible to show the influence of gum arabic (100 mg) and xanthan gum (100 mg), tween 80 (50 mg) and oil (100 mg) on the stability of formulations E1-GA and E2-GX, and the potential use in a controlled release formulation in the pharmacological administration of Eucalyptus citriodora oil.
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